To reach their full potential, Remotely Piloted Aerial System (RPAS), must operate over built-up areas such as towns and cities where there are many high-value tasks that a RPAS can perform. Flying a RPAS over built-up areas is not currently possible due to a perceived lack of safety. For this reason, there is a need for RPAS that comply with recognized safety standards (e.g. DO-178C). HI-RISE is a framework within which RPAS and innovative uses for a RPAS can be developed taking into account safety regulations and standards.